Abstract: Plants have proved to a crucial role in human lives due to their immense beneficial aspects. Plants contain many biochemical substances located in various parts of their bodies which are termed as phytochemicals. These are also termed as active secondary products or metabolites that are used to treat many human diseases. Research is going on large scale whereby plants are examined for their metabolite exudates that further generate beneficial and assertive outcomes. One such plant is which is being discussed in this context is Vitex negundo that is also known as ‘Chastetree’. This plant belongs to Verbenaceae family and has enormous certain chemical active principle ingredients in its body parts such as alkaloids, flavonoids, terpenes, saponins, lignins and so on which are basically are obtained from leaves and seeds of this plant. The most important alkaloid that was worked upon is Nishidine’. The present review paper throws light upon therapeutic and bioactive phyto compounds that are chemical constituents of economic and industrial value.