Abstract Trigonella Foenum Graceum (Menugreek) is a rich source of various essential compounds and such ingredients play an important role in treating diseases through their anti-diabetic, antiinflammatory, hepatoprotective, cardioprotective, neuroprotective, immunomodulatory, nephroprotective and antimicrobial activity. Furthermore, fenugreek seeds are a rich source of antioxidants and such ability prevents the pathogenesis of diseases through free radical scavenging activity. This review comprehensively summarizes the role of fenugreek seeds in health management with a special emphasis on modulating various physical and biochemical activities as well as in vitro and in vivo studies.