Background: Chronic Renal Disease is a fast-growing disease worldwide achieving the endemic levels. The use of NSAIDs has been associated with renal function deterioration through variable mechanisms. Present study was aimed at pharmacovigilance analysis of nonsteroidal anti-inflammatory drugs-induced chronic kidney disease at a tertiary hospital. Material and Methods: Present study was retrospective, case record-based analysis conducted in case records of patients admitted & diagnosed as nonsteroidal anti-inflammatory drugs- (NSAID) induced chronic kidney disease. Results: In present study, 48 case records evaluated. Majority patients were from 51-60 years (37.5 %) & 41-50 years age group (27.08 %), were male (68.75 %) & labourer by occupation (52.08 %)