The term ‘Dooshivisha’ denotes a variety of denatured / attenuated poisons that has not been fully excreted out from the body. It is herbal/animal/mineral poison, of which, potency is lessened due to various factors. It produces delayed or cumulative toxicity effects concerned with various Srotas. Effects such as altered complexion, discoloration, red patches on skin, oedema, urticaria etc. suggest involvement of RaktavahaSrotas to great extent. Blood-letting (Siravedha) is even mentioned as a treatment modality for Dooshivisha by Charaka. Thus, a normalcy of RaktaDhatu can prove as an important aspect of treatment of Dooshivisha. Of many available medicine options, DhatuPachak Yoga from Charaka Samhita provides a strong treatment option in case of vitiation of Dhatu. Although mentioned in treatment of VishamaJwara, they hold a special space in bringing normalcy to Dhatu in many different conditions. Owing to involvement of RaktavahaSrotas, a pharmacological review of contents of ‘Raktapachaka Yoga’ was carried out in present research. The botanical description, pharmacological properties etc. were compiled and studied from texts of Ayurveda as well as modern science. The review of these contents, viz., Patola (Trichosanthesdioica), Sariva (Hemidesmusindicus), Musta (Cyperusrotundus), Patha (Cissampelospareira) and Katuki (Picrorhizakurroa) were carried out specially to understand their role in treatment of signs and symptoms of Dooshivisha. The review revealed the promising potential of this great combination in treatment of Dooshivisha.