Research objective: to conduct a clinical and economic analysis on the efficacy of ferrous and ferric iron supplements in the treatment of iron deficiency anemia in the outpatient settings of the Republic of Uzbekistan. Material and research methods. The analysis was carried out in 3 outpatient settings of the Bukhara region of the Republic of Uzbekistan in the period from 2018 to 2020. The study included 220 patients with moderate iron deficiency anemia (Hb 70-90 g/l). Pregnant women were excluded from the study.As aninvestigational sample the most common ferrous and ferric iron supplements in the form of tablets and capsules were selected.For assessment of the clinical efficacy, westudiedthe dynamics of decrease of general anemia syndrome manifestations, the dynamics of decrease of sideropenic syndrome manifestations, Hb level increase and the severity of adverse reactions. For determination of the economic expediency of supplements administration, the cost-effectiveness ratio was calculated. Results and discussion. The analysis of the dynamics of clinical and laboratory parameters showed that the ferrous IS administration resulted in more pronounced Hb level increase in blood compared to ferric IS. The study of the dynamics of general anemia syndrome manifestations using the VAS showed that the ferric IS administration contributed to a significantly more pronounced dynamics of symptoms. It was revealedthat the ferric IS provides both sufficiently high Hb level increase and high tolerability for patients.