Main purpose of dentistry is to deliver best dental care without causing any harm to the patient. To fulfill this purpose many developments and improvement in quality of several materials have come into existence in recent year. One such newly advanced material in dentistry is PEEK. PEEK is a metal free, semi-crystalline, high performance, beige-brown color material with excellent mechanical properties. This article is aimed to review on the clinical application of PEEK in Prosthodontics. An electronic literature search was done via PubMed, Embasse, Google scholar and 20 full text articles were included for this review.