INTRODUCTION: The tissues investing and supporting the teeth, includes gingiva , alveolar bone, root cementum and periodontal ligament. Periodontal defects considered for reconstructive therapy may exhibit substantial loss of alveolar bone, periodontal ligament, and gingiva, whereas the root cementum is contaminated by exposure to the oral environment. In general, healing or repair with substantial tissue loss is accomplished by collagenous scar tissue that does not fully restore form and function of lost structure [1]. Periodontal repair is described in terms such as new attachment, collagen adhesion and connective tissue repair. Healing following periodontal reconstructive therapy may result in formation of a long junctional epithelium at the interface between tooth and mucogingival flap. Periodontal regeneration includes regeneration of alveolar bone, cementum, periodontal ligament, and gingiva; however, the tissue structure may not be anatomically or functionally perfect and may or may not include some evidence of scarring.