Abstract: Across these last decades, there are many circumstances where human activities have been affecting in different aspects of the environment. In this modern era emission of greenhouse gases and the practice of fossil fuel become a catastrophic global matter, which leads humankind toward an unruly environment. One is the degradation of the ozone layer. The ozone layer is key as it plays a vital role in the life of all living creatures on the planet, certain elements make the earth habitable for living creatures, one of them being the presence of the ozone layer. Life on earth is possible because of the ozone layer that covers the earth. This article is therefore aimed at revising the sources, causes, and bio effects of ozone layer depletion as well as the role of some microbes that fight greenhouse gas denitrifies. The chlorofluorocarbon and the halons are vigorous ozone depleters. The ozone layer is very distinctive because it prevents too many damaging ultraviolet radiations from radiating and attaining earth. Ultraviolet rays have such a wrecking impact on the earth and have this susceptibility to perish animals and plants and human health and major impacts on global warming and climate-changing. Although, the prospective of ozone layer restoration subsist, unexplored. In the absence of other alterations, stratospheric ozone redundancies should ascent in the future as then halogen loading pests in response to the adjustment. However, the future comportment of ozone will as well as be linked and effected through the alteration atmospheric redundancies of methane, water vapor, sulfate aerosol, nitrous oxide, and climate-changing.