In 1946 Kesling initially proposed the idea of clear orthodontic appliances to straighten teeth. In 1998, Align Technology, Inc. unveiled Invisalign®. The use of clear aligners has become much more common because of material progress and computer-aided tooth movement design. Numerous studies have demonstrated the efficiency of clear aligners in correcting almost all malocclusions, from mild to severe, with excellent results. Aim of this research is to identify and review the orthodontic literature regarding the efficiency (treatment time, chair time), effectiveness (occlusal indices) and long-term stability of treatment with clear aligners as compared to traditional orthodontic therapy. After an initial selection phase 983 records were identified from the scientific databases, the potentially eligible 8 articles were qualitatively selected to evaluate the efficiency of clear aligners as compared to conventional orthodontic treatment. Introduction The technology behind align has advanced significantly in recent years. Given the choice, many patients prefer clear aligners over traditional brackets due to their improved comfort and aesthetics, albeit their efficacy is still debatable. It was still unclear as to whether transparent aligners may be a good substitute for braces (1) In 1946 Kesling initially proposed the idea of clear orthodontic appliances to straighten teeth (2). In 1998, Align Technology, Inc. unveiled Invisalign®. The use of clear aligners has become much more common because of material progress and computer-aided tooth movement design. Numerous studies have demonstrated the efficiency of clear aligners in correcting almost all malocclusions, from mild to severe, with excellent results (3,4). While concerns about clear aligners replacing traditional orthodontics have grown in recent years as more and more patients seek an aesthetically pleasing and comfortable orthodontic treatment method, fixed braces have been the standard and most effective orthodontic equipment for more than a century. If transparent aligners are a good alternative to braces, that is still up for debate (5). Due to the lack of conclusive proof about the efficacy of the treatments, practitioners were forced to develop treatment regimens using only their own clinical expertise and subpar evidence.