Introduction: Osteomyelitis is a painful Inflammatory disease of bone secondary to its infection often of bacterial origin that may lead to the necrosis of bone tissue. It frequently involvesmetaphysis of long bones of knee but isolated involvement of diaphyseal region of fibula is a rare phenomenon . Case report: 6 year female presented with swelling, pain and discharge fromleg which was diagnosed as chronic osteomyelitis of fibula andtreated thoroughly with sequesterctomy and antibiotic therapy which led to complete resolution of the symptoms on followup. Conclusion: early diagnosis and treatment provides favourable outcome in patients.