Background: Chronic Kidney Disease (CKD) is a global health concern with multifaceted manifestations. While systemic complications are well-documented, OroFacial manifestations in CKD remain understudied. This study aimed to comprehensively investigate the prevalence and severity of OroFacial manifestations in CKD patients in North India. Methods: A cross-sectional study was conducted at Subharti Medical College between 2016 and 2018. A total of 150 CKD patients were included. Clinical examinations assessed OroFacial manifestations, and CKD staging was based on laboratory parameters. Results: OroFacial manifestations exhibited stage-wise variations. Oral ulcers, xerostomia, and taste disturbances increased with advancing CKD stages, reaching their highest prevalence in Stage 5 CKD. Facial edema and OroFacial infections showed notable associations with moderate and advanced CKD stages. Conclusion: This study elucidates the prevalence and severity of OroFacial manifestations in CKD patients, emphasizing the importance of considering CKD stage in OroFacial assessments for improved patient care.