Teeth are being held in position by investing soft and hard tissues. A successful orthodontic therapy goes in hand with a healthy periodontium. Immaculate maintenance of oral hygiene during orthodontic therapy is a skill that is difficult to achieve with mechanical toothbrushing alone. Therefore, using auxiliaries for oral hygiene maintenance is a very important part of the routine for most patients undergoing therapy. This literature review ahead focuses on various microbial andbiological markers that are found in GCF during inflammation with inhome and in-office therapies that have been proved effective in preserving good oral health during and after orthodontic treatment.