ABSTRACT- Abiotic stress is one of the major factors which affect the growth and yield of crops. This is due to several imbalances which occur at the plants molecular, cellular and developmental levels during stress conditions. Due to these disturbances in plants, the defence mechanism gets activated in response of stress and the detection of these changes is possible because of computational biology that facilitate the multi-target approach. However, with the advancement of omics technology plants are seen to acclimatize themselves by modulating at the genomics, transcriptomics, proteomics. In this review, all the molecular changes of plants under stress is discussed and the new insights which are obtained from the integration of omics are highlighted.