Background and objective: To determine the S.S.I. risk variables. should be familiar with S.S.I.'s bacteriological profile. To research the microorganisms obtained from wounds' antibiograms. To understand their post-operative effects. Method: After consultation with the institute's ethical review board, a prospective observational study was conducted by Department of Obstetrics and Gynaecology, Rangaraya Medical College, Kakinada, Andhra Pradesh, India, from June 2021 to May 2022. The microbiology lab provided a sterile swab to collect pus or discharge from the injury site for culture and sensitivity testing. 5731 surgeries were done in130 patients (22.68%) had surgical site infections (S.S.I.). Result: 83 (63.86%) of 130 patients developed S.S.I. between 6-10 days, followed by 33 (25.38%) before 6 days. Staph. aureus was the most frequent organism, followed by E. Coli in 30 (23.08%), Klebsiella in 17 (13.08%), Pseudomonas in 11 (8.46%), Citrobacter in 4 (3.08%), and Acinetobacter in 2 (1.54%). 50 (38.46%) were sensitive to Piperacillin + Tazobactum, 42 (32.32%) were sensitive to Cefoperazone +Sulbactum, 18 (13.84%) were sensitive to meropenem, Gentamycin was 8 (6.15%), Amikacin was 6 (4.61%), Clindamycin was 3 (2.32%), Linezolid was 2 (1.53%), and 1 case was only sensitive to Levofloxacin. Conclusion: Reducing the incidence of postoperative infections in women has the potential to lower both healthcare expenses and the severity of their complications. This is feasible if the bacteriological profile and antibiotic sensitivity of the hospital's most common organism are recognized, and if the patient's risk factors for S.S.I. are identified and classified. It is possible that our S.S.I. analysis will reveal pervasive species and sensitivity trends among the sample population and the organization under examination.