Background:Recently, there has been an interest in identifying non-lipid risk factors in the causation of metabolic syndrome. Objectives: The present study was aimed to assess the significance of high sensitivity Creactive protein (hs-CRP)and thyroid profile in patients with metabolic syndrome. Materials and methods: Patients diagnosed with metabolic syndrome in the outpatient clinic of Department of Medicine were included. Those having ≥3 components of the metabolic syndrome criteria constituted the cases and those with less than three components constituted the controls. Various biochemical parameters were compared between cases and control. Results: Mean hs-CRP was significantly higher among cases (2.9 ± 0.8mg/L) as compared to controls (1.1 ± 0.7 mg/L), p value <0.05. However, thyroid stimulating hormone (TSH) was not found to be significantly higher among cases as compared to controls (p value >0.5). The clinical thyroid status of the cases was compared against that of control. Among those with metabolic syndrome, overt hypothyroidism was observed in 18.4% and 3% had subclinical hypothyroidism, while among controls, only 4.6% had overt hypothyroidism. Conclusion: Patients with metabolic syndrome had significantly higher levels of hs-CRP. Though the mean TSH levels were similar, thyroid dysfunction was significantly more common in cases with metabolic syndrome.