Abstract Aim and objective: The purpose of this study is to evaluate patients with a new diagnosis of Polycystic Ovarian Syndrome for hypothyroidism by measuring their serum thyroid stimulating hormone levels. The goal of this study is to evaluate the difference in hormone levels and other parameters between euthyroid and hypothyroid polycystic ovary syndrome patients. Materials and Methodology: This study was designed as an observational cross-section. Women over the age of puberty who presented with menstrual abnormalities for at least three months and/or infertility were recruited from the department of physiology, Kamineni Institute of Medical Sciences, Narketpally, Nalgonda clinic for our study. We started the trial before we had ultrasound proof of polycystic ovaries. The Institutional Ethic Committee allclears this study. Results: Student t-test and Chi-square test were used to compare Age, BMI, WHR, FBS, PPBS, Ovarian volume, Testosterone, and HOMA-IR between the two PCOS groups. TSH, Total Testosterone, and WHR were correlated using Pearson co-efficient. Conclusion: This hormonal discord disrupts ovarian homeostasis, which ultimately causes anovulation. The results of this study suggest that screening for hypothyroidism, along with reproductive hormone profile, should be investigated in polycystic ovary syndrome (PCOS) / infertile women to allow for early detection and treatment of the condition.