Background: Warts are very common benign tumors caused by human papilloma virus (HPV) infection, which is acquired from direct contact with an infected individual or from the environment. Plantar warts are mostly refractory to treatments and represent a therapeutic challenge.Immunotherapy has been used as a promising alternative therapeutic option in such warts. Different agents have been used as Candida albicans antigen, measles, mumps, rubella (MMR) antigen, tuberculin antigens like purified protein derivative (PPD), mycobacterium indicus pranii (formerly known as mycobacterium welchii) (Mw) vaccines and Bacillus Calmette- Guerin (BCG) vaccine and Trichophyton. The intralesional injections are thought to work by inducing a systemic T-cell mediated response inducing principal increase in the release of cytokines from Th1 cells such as IL-2 and IFN-γ.Interleukin-2 stimulates the maturation of the natural killer T cell and promotes its cytotoxicity.