Abstract: Introduction: One of the major complications of varicose veins is the nonhealing ulcer of the leg. The traditional treatment for this is regular dressing, foot end elevation with appropriate antibiotics and local application of silver-based ointments. The gold standard treatment for these patients is surgery (Trendelenburg surgery with or without venous striping and subfascial perforator ligation and endovenous procedures). Surgeons usually reach a crux when a patient develops persistent ulcers which does not heal even after all these efforts. Aim: Our objective in this study was to study the effects of Platelet Rich Plasma (PRP) in chronic non-healing post-surgical venous ulcers. Methodology: This was a case control study with 40 patients conducted over 2019 and 2020, after institutional ethical clearance. All patients were treated with appropriate antibiotics prior to the study and obtained a culture negative status. PRP was separated and injected locally into the borders of the ulcer in cases, while controls were given regular dressings with silver-based ointments. Results: We found that patients who were given PRP had a significantly faster healing rate and a lower infection rate. Conclusion: Hence PRP can be safe, effective and reasonably cost effective in treating post-surgical venous ulcers.