Background: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease with no well-known cause. The search for simple laboratory indicators is essential to assess the disease activity of the SLE. Currently, the Neutrophil Lymphocyte Ratio (NLR) and Platelet Lymphocyte Ratio (PLR) are widely used as markers of the inflammation. Methods: A cross-sectional analytic study involving 35 patients who met the criteria by Systemic Lupus International Collaborating Clinics (SLICC) 2012 was conducted during August 2019 until June 2020. The samples were obtained from outpatients and inpatients of the Rheumatology Clinic at WahidinSudirohusodo hospital and its collaborating hospitals. The data of the value of neutrophils, lymphocytes, platelets and disease activity were collected using the Mexican Systemic Lupus Erythematosus Disease Activity Index (MEX-SLEDAI). Results: Of 35 patients with SLE, all were women aged 18-51 years. The result shows that there is a significant relationship between NLR and MEX-SLEDAI scores (p <0.000). Also, PLR is significantly associated with MEX-SLEDAI scores (p <0.000).