This top to bottom examination inspects the complex associations among neuroinflammation and neurodegeneration, researching central components, recognizing biomarkers, and distinguishing potential new treatment targets. In view of broad bioinformatics, this work looked to find center point qualities and pathogenic pathways associated with neuroinflammation in irregular Creutzfeldt-Jakob sickness (SCJD). Tests of SCJD and sound people were taken from GSE160208. Key qualities were found utilizing the Limma R bundle and Weighted Quality Co-Articulation Organization Examination (WGCNA), which were then utilized for improvement and invulnerable cell penetration examinations. The primary SCJD qualities were screened utilizing the protein communication (PPI) organization, cytoHubba, and AI. By utilizing sub-atomic docking, the particles related with center qualities were anticipated and examined. 88 potential qualities were analyzed. They were essentially associated with bacterial and viral disease and safe cell enactment, as indicated by improvement examinations.