Epilepsy is categorized as a prevalent misunderstood chronic neurologic disorder. Epilepsy episodes occur as a result of abnormal neuronal excitability that was reported to occur due to a disruption depolarization and repolarization mechanisms. In addition to that, currently there are numerous studies that attribute idiopathic epilepsy to a genetic factor as it was found that there is an increased familial incidence of epilepsy. Several studies estimated that around 69 million people worldwide are diagnosed with epilepsy and it is one of the most common neurological disorders occurs to children where approximately 150,000 children experience unprovoked seizure every year, and about 30,000 of them develop epilepsy. Many of these cases demonstrated some neuropsychiatric comorbidity, which consequently affects the quality of their lives in a significant manner. Cognitive impairments might be represented as memory problems, mental defects, and attention impairment, analyzed as the most common comorbid disorders in epilepsy. Thus, it is important to analyze the factors that contribute to cognitive difficulties. Many agents was shown to have a debilitating effect on cognitive function in epilepsy such as the degree of epileptic activity and epilepsy causative factors, psychosocial status of patients in addition to surgical or therapeutic treatment of seizures.