The purpose of this study was to determine the safety and effectiveness of a nepafenac punctal plug delivery system (N-PPDS) after cataract surgery. Methods: The investigation was carried out in a single Indian clinical setting. It is a single-center, randomised, parallel-arm, double-masked, prospective pilot research. Thirty-eight participants (aged 22 and higher) with predicted postcataract correctable distant vision of 20/30 or better and lower puncta enabling dilatation up to 1.0 mm were included in the study (N-PPDS group). All of the eyes had standard unilateral cataract surgery with intraocular lens implantation. Postoperative ocular discomfort and inflammation were used as primary and secondary efficacy measures, respectively