Background:Neonatal sepsis (NS) is a potentially life-threatening clinical condition that requires early intervention. Initial symptoms are generally nonspecific and may mimic several other medical conditions. NS is an important cause of mortality and morbidity in neonatal populations. There has been constant search of an ideal sepsis biomarker with high sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV), so that both the diagnosis and exclusion of neonatal sepsis can be made at the earliest possible and appropriate antibiotics can be started to neonate. Ideal sepsis biomarker will help in guiding us when not to start antibiotics in case of suspect sepsis and total duration of antibiotics course in case of proven sepsis. A combination of increased destruction and inadequate production of platelets during sepsis-induced thrombocytopenia of the neonate may result in release of young platelets into the circulation. An increased proportion of young platelets may result in increased Mean Platelet Volume (MPV). Among platelet indices MPV is the most commonly studied platelet index in neonatal sepsis. During conditions of rapid platelet turnover, increased MPV signifies the release of larger, younger platelets into the circulation. Although MPV varies with gestational age and chronologic age, construction of rigorous normal curves for values of the MPV is difficult in premature infants