ABSTRACT Dental caries is a worldwide public health problem disturbing numerous communities. Topical fluorides have been commonly used for caries prevention and arrest. Being one of the most prevalent diseases affecting mankind in both developing and developed nation, the need for materials to establish a healthy balance between pathological and protective factor has urged for the origin of newer silver compound, Nano silver fluoride (NSF), as an alternate to overcome to drawbacks of topical fluoride and Silver Diamine Fluoride (SDF) in caries prevention. This paper aims to give an overview of the properties, indications, contraindications, advantages and disadvantages of Nano Silver Fluoride (NSF) in comparison to other recently used materials.