Aims & Objectives:Clinico-pathological analysis of all cases diagnosed as MM. To find genetic abnormalities by cytogenetics & fluorescence in situ hybridization(FISH) in this heterogenous group. Material and Method: All the cases of MM diagnosed between January 2012 to July 2014 were included in the study. The clinical details including presentation, electrophoresis, renal parameters were taken from clinical records. The bone marrow slides were retrieved and reviewed. Conventional cytogenetics and FISH analysis was performed in 14 and 8 patients respectively. Results: The study included 45 patients in the age range of 40-82 years with male predominance (M:F=1.5:1). Most of the patients (21) presented with complaints of back pain and weakness. Renal dysfunction was seen in 29 patients with mean creatinine of 2.5mg/dl. Immunoelectrophoresis revealed M band in 19 cases. The bone marrow plasma cell ranged from 15% to 90%. The commonest morphology was that of Marshalko type whereas plasmablastic type was rare. The cytogenetic abnormalities detected were aneuploidy, trisomy 1 and 9, 13q deletion. Conclusion: This study reflects our experience of 45 patients of MM with respect to clinical features, bone marrow morphology and cytogenetic analysis.