The cystic degeneration of the meniscus, or the so-called meniscus cyst, is an independent nosological unit with well-defined symptoms and a characteristic pathologo anotomical picture [1,2]. Information about this disease is almost not found in the educational literature, and only a few works have been published in the periodical foreign literature. The question of the nature of pathomorphological changes in meniscus cysts is still under discussion [3,4]. Material and methods. In the sports injury department of the Republican Specialized Scientific and Practical Medical Center for Traumatology and Orthopedics of the Ministry of Health of the Republic of Uzbekistan from 2006 to 2020 treatment was performed in 220 patients with cysts of the meniscus of the knee. All 220 patients underwent surgery. The choice of surgical treatment depended on their location, size. We examined about 50 cyst preparations together with the meniscus, removed during surgery in 18 patients aged 16 to 65 years. The duration of the disease is from 3 months to 7 years.