Study design: Prospective clinical. Objective: Evaluate efficacy of monosegmental transpedicular fixation for treatment of some thoracolumbar burst fractures. Summary: Short segment posterior fixation become a popular technique to treat thoracolumbar burst fracture. It is saving more motion segments throughout reducing fusion segment numbers, Previous investigations which used monosegmental pedicle instrumentation with placement pedicle screws into fractured vertebral body for treating thoracolumbar fracture yielded good clinical results. Method: 20 thoracolumbar burst fractures cases treated with monosegmental transpedicular fixation. All patients were followed-up radiologically and clinically. The preoperative, initial postoperative and the latest follow-up radiographs were evaluated for sagittal index, percentage of anterior body height compression and load sharing score. Clinically the latest follow-up functional outcomes were evaluated using Oswestery Disability Index and Low Back Outcome Score. Results: 20 patients were followed-up successfully with the mean follow up period was 17 months. Sagittal index value of, anterior body height compression fractured vertebra% are 19.1+/-5.4 degrees and 37.03+/-10.87, respectively, improved (statistically significant) to 10.4+/- 4.16 degrees, and 19.3+/-9.6. Conclusion: In conclusion, this study demonstrated that MSPI is effective and reliable operative technique for selected thoracolumbar burst fractures (type A3.1/A3.2)