The current epidemic of monkeypox is the largest in history to occur outside of Africa. Monkeypox is an budding zoonotic disease that for decades has been viewed as an infectious disease with outbreak potential as its occurrence is increasing in recent years. As public health entities work to contain the current outbreak, healthcare professionals globally are aiming to become familiar with the various clinical presentations and management of this infection. We present in this review an updated overview of monkeypox for healthcare professionals in the context of the ongoing outbreaks around the world.