Annotation. Systemic inflammatory response syndrome is a protective response of the body aimed at eliminating the agent that caused the inflammatory process (infection, trauma, burns and tissue necrosis, etc.). The severity of the response depends on the amount of damage inflicted. This study was conducted to assess the possibility of using the systemic inflammatory response syndrome as an independent predictor in the development of complications of acute pancreatitis. For this, the following clinical and laboratory parameters were studied: body temperature, pulse, respiratory rate and the number of leukocytes in the blood, which were obtained within the first 24 hours after hospitalization and before the development of organ failure. The relationship between the presence of systemic inflammatory response syndrome and the development of organ failure was investigated.