Abstract. At present, the attention of specialists is drawn to a new highly pathogenic strain of influenza A (H1N1) 2009, first isolated from cases in late March-April 2009 in California and Mexico, the spread of which led to a pandemic, which was announced by WHO on June 12, 2009. The aim of the study. Conduct a randomized cohort study of therapies for pregnant women with acute respiratory infections. Materials and research methods. To achieve this goal, 45 pregnant women were examined. Pregnant women were included in the examination at 12 weeks of gestation. All patients signed written consent to participate in the experiment. Of the total number of examined 22 pregnant women who did not have somatic pathology made up a comparative group. 23 pregnant women suffered influenza of varying severity in the I-II trimesters of pregnancy. The diagnosis of highly pathogenic influenza A H1N1 was confirmed by virologic testing. Of the 23 pregnant women, the main group consisted of 14 pregnant women who were treated with Viferon - the main group and 9 pregnant women who were treated with symptomatic therapy. Research results. However, in 43% of women, ARVI symptoms developed gradually over several days, which was the reason for the later admission of patients to the hospital and was often associated with the development of bacterial complications in the form of sinusitis, otitis media, acute community-acquired pneumonia or complications during pregnancy (threat of termination) ... From the analysis of the case histories, it was found that from the moment the first symptoms of acute respiratory viral infections appeared to hospitalization, it took from 2 to 7 days, on average 3.8 ± 1.2 days. In the 1st group of patients, antiviral therapy was prescribed from the first day of admission to the hospital. The effectiveness of treatment was assessed by the duration of clinical symptoms of the disease, the development of complications and pregnancy outcomes. Typical manifestations of ARVI in pregnant women upon admission to the hospital were: rhinitis - in 82% of patients, cough - in 64.2% of pregnant women, sore throat - in 57.1% of women. Dyspeptic manifestations in the form of nausea, vomiting, diarrhea occurred in 5.2% of patients. Intoxication symptoms in the form of weakness, chills, headache were recorded in 86% (20 women).