Introduction: Dengue fever, a mosquito-borne disease that occurs in tropical and subtropical areas of the world, is considered to be a significant threat for the mankind in both developing and developed countries.It causes a wide spectrum of illness from mild asymptomatic illness to severe fatal dengue hemorrhagic fever/dengue shock syndrome. Its impact today is thirty times >50 years ago. Global incidence of dengue has drastically upped in the last few years. Materials and Methods: The study was carried out in the department of microbiology at Government general hospital,siddipet fpr a period of one year , that is from January 2019 to December 20219. Blood was collected from each patient suspected to be suffering from dengue, at least 3 days after onset of fever. Serum was tested for the presence of dengue NS1 antigen and antihuman IgM antibodies using Panbio Dengue Early enzyme-linked immunosorbent assay (ELISA) kit and National Institute of Virology. Results: A total of samples 2251 were tested over a period of one years i.e. from January 2019 to December 2019. Out of which 592 (26.29%) were sero-positive for dengue with symptoms of classical dengue fever. IgM in 349(58.9%) NS1- 243 (41.04%). Conclusion: As vaccines or antiviral drugs are not available for dengue viruses, the only effective way to prevent dengue is to control the mosquito vector, Aedes aegypti and prevent its bite.