Introduction. Dental Biofilm or plaque is an assembly of microbial cells attached to a surface encased in the extracellular polymeric substance, which plays a crucial role in infection persistence. Oral infections are caused by opportunistic pathogens that exist in normal balanced microflora of the oral cavity, but become pathogenic upon any alteration in the typical biological environment of the oral cavity giving them favorable conditions. The early colonizers such as Streptococci enhance the infectivity by remodeling the oral microbiome and the metabolome. This remodeling may allow other pathogenic Streptococcus strains such as S.mitis, S.oralis, S.sanguia S. gordonii, S.mutans to colonize, which can potentially cause problems due to their inherent resistance to antibiotics and ability to form biofilms.