Many people are at risk of developing mental health problems due to the current pandemic. However, little has been explored about the magnitude of the risk to psychological factors to gender and their location and designation in the context of the current pandemic. Hence, the purpose of this study was to investigate the psychological impact on the Ethiopian population. METHODS An online survey using google form with 310 Ethiopian respondents was conducted. The adopted questionnaire covers the participant's sociodemographic information, and three different questionnaires (mental health inventory, self-esteem, and life satisfaction) used to collect data. The data were not distributed normally. The Mann-Whitney U-test was applied to find differences between different categories of mental health, self-esteem, and life satisfaction. RESULTS The results indicate that urban males have higher mental health and self-esteem compared to females, and little difference in mental health appeared between students, academics, government employees, private employees, and business people. Females belonging to the rural area have higher life satisfaction than males. A significant difference in self-esteem and life satisfaction was found between participants belonging to different designations. CONCLUSION The results of all these psychological factors provide a comprehensive picture of Ethiopianpeoples during the current pandemic. In such stressful situations, the concerned government, hospitals, educational institutions, organizations and individuals need to consider psychological intervention and take necessary action. In addition to educate and prepare individuals for the various mental health issues that they may face during the pandemic period.