Hypertension is one among the leading non communicable disease that affects the people worldwide. It is the most prevalent trigger for morbidity and mortality associated with CVD’s and its complications. Although, so many conventional drugs are prevalent for high blood pressure, people are still in search for traditional herbal medicines due to their safety and efficacy. The different constituents in herbal medicine plays a multitarget and synergistic role in the treatment of Hypertension. Veppampoo mathirai, a polyherbal siddha formulation containing fifteen herbs was found to be effective in reducing blood pressure which had been practised since decades. But, the mechanism of action is not known yet. However, it is very important to validate the potential of the herbal medicines scientifically, which are in practise, so that it might help them to establish with authentication for further use