Aims: The present study was designed to compare Mean platelet Volume to Lymphocyte ratio (MPVLR) as predictor of inflammatory marker in patients with Diabetic nephropathy and diabetics without nephropathy. Materials & methods: The study was conducted on 50 diabetic patients with nephropathy and 50 diabetics without nephropathy that presented to Medicine department (indoor/ outdoor department) of Guru Nanak Dev Hospital, Amritsar. The subjects were divided into two groups i.e. Group A and Group B. Group A comprised of 50 Diabetic patients with Nephropathy and Group B comprised of Diabetic patients without Nephropathy. Detailed history was taken and all patients underwent a detailed clinical evaluation including measurement of vitals. Plasma glucose, Blood urea, Serum creatinine were estimated by standard protocols. Urine complete examination was done microscopically. Albuminuria, which is the hallmark of diabetic nephropathy, was estimated using spot Urinary Albumin-creatinine ratio (UACR). The quantitative determination of microalbuminuria was done by Nephelometry method procuring commercially available kits. Mean Platelet Volume (MPV) and Absolute Lymphocyte Count (ALC) were calculated using cell counter (ABX Pentra 80) and then ratio was calculated by dividing MPV to ALC.