Introduction: Acute kidney injury is a global health burden that is associated with high incidence of morbidity and mortality .There are not much studies about the already available parameters of complete blood count. Mean Platelet Volume can be an investigation that can be put for in-depth study to know the prognosis of acute kidney injury. Methods: This cross sectional study was carried out in acute kidney injury patients for a period of 2 years from September 2016 to September 2018. Blood report of mean platelet volume including red blood cell distribution width were collected. Result: It was seen that patients belonging to middle age between 31-50 years constituted the majority of the cases of acute kidney injury. It was shown that patients having a lower values of Mean Platelet Volume are more prone for the requirement of dialysis when the two groups were compared to look for significance in predicting the requirement of dialysis (P=0.03) Improvement after dialysis was better in patients with higher values of Mean Platelet Volume than patients with lower values of Mean Platelet Volume even though the difference between the values of Mean Platelet Volume were not significant. (P=0.568) There is a negative correlation between values of creatinine and Mean Platelet Volume (P <0.001). Conclusion: Mean Platelet Volume could be inexpensive and superior investigation to creatinine in early detection of acute kidney injury which needs to be studied further with larger sample size .