Background: Abdominal surgeries typically elicit significant levels of pain after the operation, which can create patient discomfort and dissatisfaction. Pain relief must be optimized to enable a better patient outcome and enable recovery. The abdominal fascial plane blocks with liposomal bupivacaine and plain local anesthetic are now considered efficient approaches for postoperative pain management. Nevertheless, it is still difficult to say which of these drugs are more effective. Methods: We performed a randomized controlled trial which was aimed at comparing the efficacy of liposomal bupivacaine to plain local anesthetics for abdominal fascial plane blocks in patients undergoing elective abdominal surgeries. Patients were randomly assigned to get either liposomal bupivacaine or just local anesthetics, and then pain scores, opioid consumption, adverse events, and the level of patient satisfaction were measured after the surgery. Results: Patients who received liposomal bupivacaine had a significantly reduced mean pain score at all the postoperative time points than those who received conventional local anesthetics. Moreover, liposomal bupivacaine was linked with decreased opioid prescription, less occurrence of adverse effects, and higher patient satisfaction scores. Conclusion: Our study demonstrated that liposomal bupivacaine provided more effective pain control and produced better outcomes of the patients who underwent elective abdominal surgeries when compared to the plain local anesthetics delivered through abdominal fascial plane blocks. The use of liposomal bupivacaine for postoperative pain management may allow for optimization of the pain treatment and enhance the patient satisfaction in the perioperative period.