Background: Sphygmomanometer, blood pressure instrument, measure blood pressure of one side of arm at one time, consists of an inflatable cuff to collapse and then release the artery under cuff in a controlled manner. 0 to 30 mmHg points or more variation of blood pressure and pulse rate occurs in human beings in inter-arm. Blood pressure of normal adult is approximately 120/80mmHg and pulse rate is 70-80/minute. Blood pressure and pulse rate variation may lead to misdiagnosis of hypertension and hypotension. Method: Apparatus used are digital sphygmomanometers. Blood pressure and pulse rate is measured of both arms turn by turn and simultaneously by using two digital sphygmomanometer, thrice, the concordant readings are considered and noted for this purpose of blood pressure and pulse rate, in different age groups persons and average real variability method is also used to estimate blood pressure and pulse variation. Data is collected from different rural areas by gathering people, on some fixed places, or by visiting in different rural areas. Result: Total Persons of different age groups investigated = 1765, Males = 834(47.25%), Females = 931 (52.75%). SBPV persons in 0-10 mmHg= 76.99%, 11-20mmHg= 21.42%, 21- 30mmHg = 1.59%. DBPV in persons with variation from 0-10mmHg = 92.18%, 11-20mmHg= 7.14%, 21-30mmHg = 0.68%, PV in persons from 0-10mmHg= 95.86%, 11-20mmHg = 3.68%, 21-30mmHg= 0.45%. Diseased persons = 22.38% (Hypertension, diabetic mellitus type I and type II, hypotension, kidney diseases, chronic and obstructive pulmonary diseases), Normal Persons= 77.62%. Conclusion: Variation in inter-arms in systolic blood pressure and diastolic blood pressure and pulse is observed when detected with sphygmomanometer, thrice in each arm turn by turn or by using two instruments simultaneously in both the arms, concordant readings are considered and average real variability method is also used to estimate blood pressure and pulse variation. Variation in blood pressure and pulse rate in inter-arms observed in different age groups, ranged from 0-10mmHg to 21-30mmHg. Maximum persons have variation in 0- 10mmHg in systolic blood pressure, diastolic blood pressure and pulse which is not showing significant diseases and persons in 11-20 and 21-30mmHg variations show cardiovascular diseases or have probabilities.