The rich initial materials collected in the selection process allow the creation of intensive cotton varieties. Organological evaluation of complex economic indicators, resistance to wilt, drought tolerance, seed oil content, botanical morphological features, and degree of phenotype similarity has been performed in hybrid, selection, and sorting materials at all stages of the selection process. Extensive research is being conducted to create new cotton varieties that are tolerant to all kinds of extreme conditions and have more potential than their predecessors. Highly productive cotton varieties Ganja-110, Ganja-114, Ganja-132, Ganja-160, and Ganja-182 have been developed as a result of directional selection. These fast-growing varieties with high fiber yield and high-tech quality were tolerant to wilt disease and cultivated on farms. Their initial seed growing work was started, original and superelite seeds were prepared.