BACKGROUND:Subclinical hypothyroidism (SCH) is defined as an elevated serum thyroidstimulating hormone (TSH) level with a normal serum free tri-iodothyronine (FT3) & free thyroxine(FT4) concentration. Hypothyroidism is associated with dyslipidemia and increased risk of atherosclerosis. SCH can progress to overt hypothyroidism. Lipid profile changes in SCH, however, are controversial. AIMS AND OBJECTIVES: To study the lipid profile in patients with SCH. MATERIAL & METHODS:The present study was a case-control study involving 35 individuals with newly diagnosed / untreated SCH were studied. 35 age and sex matched adults with normal thyroid profile were taken as controls. Serum TSH, FT3, FT4, Total cholesterol, Triglyceride, Low density lipoprotein cholesterol (LDL-C), High density lipoprotein cholesterol (HDL-C)and Very low density lipoprotein cholesterol(VLDL-C) levels were measured in all study subjects. RESULTS: The average total cholesterol and LDL-C in the patients with SCH in our research were statistically significantly higher than the control group. The mean serum triglyceride, HDL-C and VLDL-C levels were not statistically different in patients as compared to controls. CONCLUSION: SCH is associated with dyslipidemia which is a risk factor for atherosclerosis, with a resultant risk of cardiovascular disease and stroke. Thus, it is important to detect this condition early so that appropriate steps may be taken to prevent its deadly complications.