Lignocaine is useful to decrease sympathetic response to laryngoscopy and intubation when applied topically or sprayed or nebulised or gargled providing sensory blockade in the airway. Intravenous administration is advantageous. Lignocaine at 1.5 mg/kg intravenous has been recommended before laryngoscopy and intubation. Optimal time of administration is 3 min before laryngoscopy and intubation16. Therapeutic concentration is achieved earlier than topical use. A clinical comparative prospective study of attenuation of sympathetic response to laryngoscopy and intubation was done in 150 patients posted for elective surgeries. General anaesthesia was provided with endotracheal intubation for all the patients. Patients undergoing various Orthopaedic, Ear, Nose and Throat surgeries, Gynaecological, Neurosurgical and Laparoscopic procedures were selected. Following criteria’s were adopted for selecting patients. There appeared no significant difference in heart rate at pre and post induction levels between lignocaine and fentanyl groups (p=0.42 and 0.97). The heart rate response between lignocaine and fentanyl groups was statistically highly significant at 1 and 3 minutes (p<0.001) and significant at 5 minutes (p<0.01) after the onset of laryngoscopy and intubation.