Aim: The aim of this study to compare the laparoscopic cholecystectomy with and without drains Methods: This randomized controlled trial single-blind study was done the Department of General Surgery, Anugrah Narayan Magadh Medical College, Gaya, Bihar, India. 200 patients were included in this study. Patients were divided into 2 groups; A with drain and B without drain. A complete history, physical evaluation, the relevant investigations were done and the post-operative period and complications were assessed. Patients were grouped by simple random sampling. Results: Patients with cholelithiasis were divided into two groups: those who had a drain and those who did not. Patients with acute cholecystitis were 27 percent more likely to have a drain than they were to be without one, while patients with chronic cholecystitis were 31 percent more likely to have a drain than they were to be without one. There was no statistically significant difference between the two groups. Patients with drains received a G4 (49 percent), followed by a G3 (47 percent), and finally a G2 (22 percent) (5 percent). Patients who did not have a drain had a VAS grade of G2 (49 percent), followed by G3 (30 percent), and then G1 (15 percent). There was a statistically significant difference between the two groups when the p-value was less than 0.05. Wound infection was observed in 12 (12 percent) of the patients with drains and 1 (1 percent) of the patients without drains, resulting in a p value of 0.006. Consequently, the researchers discovered a statistically significant difference between the two study groups. The mean length of stay in the hospital for patients with drains was 9.152.03 days, while the mean length of stay in the hospital for patients without drains was 4.111.36 days. There was a statistically significant difference between the two study groups, as indicated by a p-value of 0.05. The presence of nausea and vomiting was observed in 45 (45 percent) of the patients with drains and 3 (3 percent) of the patients without drains, resulting in a p value less than 0.05. Conclusions: Uncomplicated gallstone disease can be treated by laparoscopic cholecystectomy without the need for a drain with tolerable safety if performed by an experienced surgeon with the appropriate training and equipment.