Abstract: Objective. To determine the relationship between knowledge and the practice of preventive control of cervical cancer. Methods. A correlational study was carried out with 120 housewives attending the CLAS Pillcomarca in Huánuco 2017. In the data collection a knowledge questionnaire and a practice questionnaire were used. For the inferential analysis of the results, the Chi Square Test of independence was used. Results. 50.0% (60 housewives) presented regular knowledge about cervical cancer and 90.8% (109 housewives) had preventive cervical cancer control practices. On the other hand, a significant relationship was found between the knowledge about cervical cancer and preventive control practices (p 0,000). And, the general knowledge of the disease and knowledge about the prevention of the disease relate to the preventive control practices of cervical cancer (p 0.000). Conclusions. There is a significant relationship between the knowledge about cervical cancer and the preventive control practices of cervical cancer of housewives attending the CLAS Pillcomarca - Huánuco.