Antibiotics primarily used in treating the bacterial infections when administered unnecessarily can cause antibiotic resistance making the bacteria non responsive against antimicrobials. Analgesics that are used to relieve pain are one of the routinely used medications. Hence, the aim of this study was to check the knowledge and awareness regarding use of both antibiotics and analgesics amongst dental undergraduates. Total 324 participants from different profs and interns submitted their responses for the online questionnaire. A highly statistically significant difference was observed in the knowledge of participants for both analgesics and antibiotics. It can be concluded that the knowledge and awareness on the use of antibiotics and analgesics among dental undergraduates is low indicating lack of basic understanding of oral dose, indications and risks of both medications