SLE or Systemic Lupus Erythematosus is known as an autoimmune disease, usually affect multiple systems include the eyes organ. We report a 26-year-old female, complained about painless blurred vision in the right eye since 6 months ago. The examination result shown no history of lowgrade fever, fatigue, photosensitivity, arthralgia, and hair loss, erythema over the cheeks, neck, hands, chest, and back. The visual acuity examination of the right eye was 1/300, keratic precipitates and band keratopathy were not found while posterior synechiae were found. Visual acuity of left eyes was 6/40 and was found normal from anterior to the posterior’s segment. Ultrasonography (USG) test showed severe OD. Severe Vitreous Opacity (suspect chronic inflammatory), but retina in its place. A serological test revealed positive PCNA with 25 intensity, negative RF, and negative ANA IFA results. The patient was consulted to the internal medicine department and was diagnosed with systemic SLE with ocular involvement. For eight weeks Oral corticosteroid was given. Six weeks after treatment, the opacity of the vitreous had decreased and the visual acuity of the right eye has improved. A case of uveitis in SLE disease can be treated with corticosteroid therapy. Management needs to be holistic, both systemic and ocular. SLE systemic management generally improves ophthalmological outcome.