Background: As a world crisis, the COVID-19 pandemic has significantly affected educational status. Nursing students tolerate more stress compared to other students due to the nature of their major. Therefore, this study aimed to investigate general health and its related factors in final year nursing students during the COVID-19 pandemic. Methods: The current study was a descriptive- cross-sectional study. Samples included all final year nursing students of Shiraz nursing faculty (106 individuals) that were invited to participate in the study using the census sampling method. Demographic information questionnaires, as well as Goldberg`s General Health questionnaire, were utilized to collect the data. The data were analyzed using SPSS, version 22, software. Results: The results of the study indicated that nursing students were not in the complete health level regarding the general health index (44.07±12.3). Moreover, factors such as underlying disease history, and history of Coronavirus infection, as well as the history of virus infection in one of the family members had a significant relationship with general health score (p<0.05). Conclusion: The results of the study showed that nursing students were exposed to injuries regarding the general health index; this issue was mostly true for students having underlying diseases and those who were infected with COVID-19. Therefore, considering the general health dimensions of the nursing students seemed necessary.