Purpose: The purpose of this study was to determine the hemodynamic effect of intravenous lornoxicam during laryngoscopy and endotracheal intubation and to determine whether intravenous lornoxicam is effective in reducing the hemodynamic stress response to laryngoscopy and endotracheal intubation. Methods: It was a double blind randomized control trial to investigate the effect of lornoxicam on the change in blood pressure, heart rate observed during laryngoscopy and tracheal intubation in 50 ASA class I and II patients. 50 patients with similar characteristics were divided into groups of 25 each. One group received lornoxicam, while the other received a placebo. Results: Blood pressure and heart rate was recorded at various intervals during laryngoscopy and endotracheal intubation. It was observed that there was a significant attenuation in heart rate and blood pressure response to laryngoscopy and intubation for the lornoxicam group. Conclusion: The use of IV lornoxicam during laryngoscopy and intubation can save lives since it significantly lowers the hemodynamic reactions to intubation when administered 30 minutes prior to the surgery. Key Words: Blood Pressure, Catecholamine’s , IV, Lornoxicam, Mean Arterial Pressure , Normal Saline, Placebo Introduction Laryngoscopy and intubation are associated with a transient cardiovascular stress response characterized by hypertension and an increase in circulating catecholamines. This was known as early as 1951 [1]. This is of little consequence to most of the patients, but increases morbidity and mortality in patients with coronary arterial disease, systemic hypertension, preeclampsia, increased intraocular pressure, and cerebrovascular pathologies such as tumors, aneurysms, or increased intracranial pressure. Several techniques, such as deepening anesthesia, omitting anticholinergic premedication, and pretreatment with vasodilators such as nitroglycerine, beta blockers, calcium channel blockers, and opioids, have been proposed to prevent or mitigate hemodynamic responses following laryngoscopy and intubation [2, 3]. The recent studies aimed at controlling or attenuating the hemodynamic response to intubation and laryngoscopy focused on the effectiveness of lornoxicam at different dosing regimens [3]. The study's objective is to determine the hemodynamic effect of intravenous lornoxicam during laryngoscopy and endotracheal intubation and to determine whether intravenous lornoxicam is effective in reducing the hemodynamic stress response to laryngoscopy and endotracheal intubation