Background and Objective: Laparoscopic surgery has now become the most accepted surgical and safe technique for a number of surgery including cholecystectomy , appendcectomy , etc .Advantages over open procedures include lesser haemorrhoage , better cosmetic results , lesser post operative pain and better results . To compare the analgesic effect of intraperitoneal application of bupivacaine and bupivacaine with dexmedetomidine in laparoscopic cholecystectomy . To assess the quality of analgesia by visual analgesia scale score (VAS). Material and Method: This study was an interventional, prospective, double blind, parallel group, randomised clinical study conducted on patients undergoing laparoscopic cholecystectomy surgeries. Institutional Ethical Committee Approval was obtained and written informed consent was obtained from all the patients before the screening in the study. Total of 162 patients were selected in which 81 were randomly allocated in each group using table of randomisation. Study Duration Period 2 Sep 2020 To 2 March 2021. Conclusion: Hence our study showed that intraperitoneal instillation of dexmedetomidine 1 µgm/kg in combination with bupivacaine 0.25% in elective laparoscopic cholecystectomy significantly reduces the post-operative pain and significantly reduces the analgesic requirement in post-operative period as compared to bupivacaine 0.25% alone