ABSTRACT Development of the dosage form aimed for safe, effective and easy administration according to that ideal way is the oral route, but great challenges stop against that like poor absorption, enzymatic degradation, low solubility and gastric effect all these barriers present in the GIT. Intestinal patch with it is a unique design, consist of protective and mucoadhesive parts resemble transdermal patch that provide good chance for developing an oral dosage form to the proteins, peptides, aminoglycoside and low permeable drugs near look about this oral intestinal device in this review.