Abstract: This research work deals with the design, fabrication and evaluation study of floating tablets using hydrophilic and hydrophobic based polymers, Hydroxy Propyl Methyl Cellulose (HPMC K4M), a hydrophilic polymer and ethyl cellulose a hydrophobic polymer. Xanthane gum was used as a swelling agent and sodium bicarbonate & citric acid at various compositions were used as a gas forming agent by wet granulation techniques. Metronidazole (MZ) was used as an antibiotic, amebicide, and antiprotozoal as a standard drug. The invitro dissolution study of Metronidazole floating tablets was carried out by USP Type- II dissolution test apparatus in 0.1N HCl at 37°C±0.5°C at 50 rpm for 12 hours. All prepared tablets were undergone compatibility study using Fourier transform infrared spectroscopy (FTIR) and Differential scanning calorimetric (DSC). No significant change in MZ drug and combination of drug and other excipients were detected. The percentage of drug dissolved in floating tablet was found to be 98.67 % at the end of 12 hrs. The kinetic release data were analyzed which showed zero order kinetic and is best fit with Higuchi model. The optimized formulation of tablet was formulated by combination of HPMC K4 M and Ethyl Cellulose gives floating lag time and sustained drug release characteristics. The novelty behind the hydrophilic-hydrophobic polymers combined formulations resulted controlled drug release duration reduced the dose frequency and prolonged the retention time of stomach.